Details

Autor(en) / Beteiligte

• Postmus, Iris
• Warren, Helen R
• Trompet, Stella
• Arsenault, Benoit J
• Avery, Christy L
• Bis, Joshua C
• Chasman, Daniel I
• de Keyser, Catherine E
• Deshmukh, Harshal A
• Evans, Daniel S
• Feng, QiPing
• Li, Xiaohui
• Smit, Roelof A J
• Smith, Albert V
• Sun, Fangui
• Taylor, Kent D
• Arnold, Alice M
• Barnes, Michael R
• Barratt, Bryan J
• Betteridge, John
• Boekholdt, S Matthijs
• Boerwinkle, Eric
• Buckley, Brendan M
• Chen, Y-D Ida
• de Craen, Anton J M
• Cummings, Steven R
• Denny, Joshua C
• Dubé, Marie Pierre
• Durrington, Paul N
• Eiriksdottir, Gudny
• Ford, Ian
• Guo, Xiuqing
• Harris, Tamara B
• Heckbert, Susan R
• Hofman, Albert
• Hovingh, G Kees
• Kastelein, John J P
• Launer, Leonore J
• Liu, Ching-Ti
• Liu, Yongmei
• Lumley, Thomas
• McKeigue, Paul M
• Munroe, Patricia B
• Neil, Andrew
• Nickerson, Deborah A
• Nyberg, Fredrik
• O'Brien, Eoin
• O'Donnell, Christopher J
• Post, Wendy
• Poulter, Neil
• Vasan, Ramachandran S
• Rice, Kenneth
• Rich, Stephen S
• Rivadeneira, Fernando
• Sattar, Naveed
• Sever, Peter
• Shaw-Hawkins, Sue
• Shields, Denis C
• Slagboom, P Eline
• Smith, Nicholas L
• Smith, Joshua D
• Sotoodehnia, Nona
• Stanton, Alice
• Stott, David J
• Stricker, Bruno H
• Stürmer, Til
• Uitterlinden, André G
• Wei, Wei-Qi
• Westendorp, Rudi G J
• Whitsel, Eric A
• Wiggins, Kerri L
• Wilke, Russell A
• Ballantyne, Christie M
• Colhoun, Helen M
• Cupples, L Adrienne
• Franco, Oscar H
• Gudnason, Vilmundur
• Hitman, Graham
• Palmer, Colin N A
• Psaty, Bruce M
• Ridker, Paul M
• Stafford, Jeanette M
• Stein, Charles M
• Tardif, Jean-Claude
• Caulfield, Mark J
• Jukema, J Wouter
• Rotter, Jerome I
• Krauss, Ronald M

Titel

Meta-analysis of genome-wide association studies of HDL cholesterol response to statins

Ist Teil von

• Journal of medical genetics, 2016-12, Vol.53 (12), p.835-845

Ort / Verlag

England: BMJ Publishing Group LTD

Erscheinungsjahr

2016

Quelle

BMJ Journals Archiv - DFG Nationallizenzen

Beschreibungen/Notizen

• BackgroundIn addition to lowering low density lipoprotein cholesterol (LDL-C), statin therapy also raises high density lipoprotein cholesterol (HDL-C) levels. Inter-individual variation in HDL-C response to statins may be partially explained by genetic variation.Methods and resultsWe performed a meta-analysis of genome-wide association studies (GWAS) to identify variants with an effect on statin-induced high density lipoprotein cholesterol (HDL-C) changes. The 123 most promising signals with p<1×10−4 from the 16 769 statin-treated participants in the first analysis stage were followed up in an independent group of 10 951 statin-treated individuals, providing a total sample size of 27 720 individuals. The only associations of genome-wide significance (p<5×10−8) were between minor alleles at the CETP locus and greater HDL-C response to statin treatment.ConclusionsBased on results from this study that included a relatively large sample size, we suggest that CETP may be the only detectable locus with common genetic variants that influence HDL-C response to statins substantially in individuals of European descent. Although CETP is known to be associated with HDL-C, we provide evidence that this pharmacogenetic effect is independent of its association with baseline HDL-C levels.