Brain, behavior, and immunity, 2017-07, Vol.63, p.197-209
2017
Details
- Autor(en) / Beteiligte
- Titel
- Role of microglia in a mouse model of paediatric traumatic brain injury
- Ist Teil von
- Brain, behavior, and immunity, 2017-07, Vol.63, p.197-209
- Ort / Verlag
- Netherlands: Elsevier Inc
- Erscheinungsjahr
- 2017
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • TBI in neonates leads to tissue loss and microglia/macrophage activation over several days. • Microglia/macrophage are predominantly of a reparatory/regenerative or immunomodulatory type after neonatal TBI. • Microglia/macrophage inhibition (using minocycline) after TBI is only transiently neuroprotective.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0889-1591, 1090-2139eISSN: 1090-2139DOI: 10.1016/j.bbi.2016.11.001Titel-ID: cdi_swepub_primary_oai_gup_ub_gu_se_248130
- Format
- –
- Schlagworte
- Allergy and Immunology, Animals, Apoptosis, Brain - metabolism, Brain Injuries - immunology, Brain Injuries - metabolism, Brain Injuries, Traumatic - immunology, Brain Injuries, Traumatic - metabolism, Cerebral, Chemokine, Chemokines - immunology, Chemokines - metabolism, Cytokine, Cytokines - immunology, Cytokines - metabolism, Disease Models, Animal, Fysiologi, Immature, Inflammation, Macrophage, Macrophage Activation - drug effects, Macrophage Activation - immunology, Macrophage Activation - physiology, Macrophages - metabolism, Mice, Microglia - metabolism, Minocycline, Minocycline - pharmacology, Neuron, Phenotype, Physiology, Psychiatry, Special Issue on Perinatal Inflammation