Details

Autor(en) / Beteiligte

• Koh, Ara
• De Vadder, Filipe
• Kovatcheva-Datchary, Petia
• Bäckhed, Fredrik

Titel

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

Ist Teil von

• Cell, 2016-06, Vol.165 (6), p.1332-1345

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• A compelling set of links between the composition of the gut microbiota, the host diet, and host physiology has emerged. Do these links reflect cause-and-effect relationships, and what might be their mechanistic basis? A growing body of work implicates microbially produced metabolites as crucial executors of diet-based microbial influence on the host. Here, we will review data supporting the diverse functional roles carried out by a major class of bacterial metabolites, the short-chain fatty acids (SCFAs). SCFAs can directly activate G-coupled-receptors, inhibit histone deacetylases, and serve as energy substrates. They thus affect various physiological processes and may contribute to health and disease. A surprisingly diverse set of activities carried out by the microbial metabolites known as short-chain fatty acids may provide some of the key mechanistic links between diet, microbiota, and host physiology.