International journal of cardiology, 2013-09, Vol.167 (5), p.1677-1687
2013
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- Autor(en) / Beteiligte
- Titel
- The past, present and future of renin–angiotensin aldosterone system inhibition
- Ist Teil von
- International journal of cardiology, 2013-09, Vol.167 (5), p.1677-1687
- Ort / Verlag
- Shannon: Elsevier Ireland Ltd
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Abstract The renin–angiotensin aldosterone system (RAAS) is central to the pathogenesis of cardiovascular disease. RAAS inhibition can reduce blood pressure, prevent target organ damage in hypertension and diabetes, and improve outcomes in patients with heart failure and/or myocardial infarction. This review presents the history of RAAS inhibition including a summary of key heart failure, myocardial infarction, hypertension and atrial fibrillation trials. Recent developments in RAAS inhibition are discussed including implementation and optimization of current drug therapies. Finally, ongoing clinical trials, opportunities for future trials and issues related to the barriers and approvability of novel RAAS inhibitors are highlighted.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0167-5273, 1874-1754eISSN: 1874-1754DOI: 10.1016/j.ijcard.2012.10.007Titel-ID: cdi_swepub_primary_oai_gup_ub_gu_se_166891
- Format
- –
- Schlagworte
- Angiotensin-Converting Enzyme Inhibitors - pharmacology, Angiotensin-Converting Enzyme Inhibitors - therapeutic use, Animals, Antihypertensive Agents - pharmacology, Antihypertensive Agents - therapeutic use, Arterial hypertension. Arterial hypotension, Biological and medical sciences, Blood and lymphatic vessels, Cardiology. Vascular system, Cardiovascular, Clinical Medicine, Clinical trials, Clinical Trials as Topic - methods, Coronary heart disease, Heart, Heart failure, Heart Failure - drug therapy, Heart Failure - physiopathology, Heart failure, cardiogenic pulmonary edema, cardiac enlargement, Humans, Hypertension, Hypertension - drug therapy, Hypertension - physiopathology, Klinisk medicin, Medical sciences, Myocardial infarction, Myocarditis. Cardiomyopathies, Renin-Angiotensin System - drug effects, Renin-Angiotensin System - physiology, Renin–angiotensin aldosterone system