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The MYB-NFIB gene fusion-a novel genetic link between adenoid cystic carcinoma and dermal cylindroma
The Journal of pathology, 2011-07, Vol.224 (3), p.322-327
Fehr, A
Kovács, A
Löning, T
Frierson Jr, HF
van den Oord, JJ
Stenman, G
2011
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Fehr, A
Kovács, A
Löning, T
Frierson Jr, HF
van den Oord, JJ
Stenman, G
Titel
The MYB-NFIB gene fusion-a novel genetic link between adenoid cystic carcinoma and dermal cylindroma
Ist Teil von
The Journal of pathology, 2011-07, Vol.224 (3), p.322-327
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2011
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
We have recently shown that the recurrent t(6;9)(q22 ∼ 23;p23 ∼ 24) translocation in adenoid cystic carcinoma (ACC) of the breast and head and neck results in a fusion of the two transcription factor genes MYB and NFIB. Here we demonstrate, for the first time, that benign sporadic, dermal cylindromas also express the MYB–NFIB gene fusion. RT–PCR and immunohistochemical analyses revealed that eight of 12 analysed tumours (67%) expressed MYB–NFIB fusion transcripts and/or stained positive for MYB protein. Nucleotide sequence analyses confirmed that the composition of the chimeric transcript variants identified was identical to that in ACC, suggesting a similar molecular mechanism of activation of MYB in cylindroma as in ACC. In contrast, no evidence for the presence of the MYB–NFIB fusion was found in other types of basaloid skin and salivary gland tumours, indicating that the fusion indeed has a restricted expression pattern. Our findings broaden the spectrum of neoplasms associated with MYB oncogene activation and reveal a novel genetic link between ACC and dermal cylindroma. These results, together with our previous observations, further strengthen the evidence for common molecular pathways of importance for the development of both benign and malignant breast, salivary and adnexal tumours. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0022-3417, 1096-9896
eISSN: 1096-9896
DOI: 10.1002/path.2909
Titel-ID: cdi_swepub_primary_oai_gup_ub_gu_se_151216
Format
–
Schlagworte
80 and over
,
Adenoid
,
adenoid cystic carcinoma
,
Adenoid Cystic/genetics/metabolism/pathology
,
Aged
,
Aged, 80 and over
,
Benign
,
Biological and medical sciences
,
Carcinoma
,
Carcinoma, Adenoid Cystic - genetics
,
Carcinoma, Adenoid Cystic - metabolism
,
Carcinoma, Adenoid Cystic - pathology
,
Cell and Molecular Biology
,
Cell- och molekylärbiologi
,
Chromosome aberrations
,
chromosome translocation
,
Chromosomes
,
Chromosomes, Human, Pair 6 - genetics
,
Chromosomes, Human, Pair 9 - genetics
,
dermal cylindroma
,
Female
,
fusion gene
,
Fusion/genetics
,
Gene fusion
,
Genetic
,
Human
,
Humans
,
Investigative techniques, diagnostic techniques (general aspects)
,
Male
,
Medical genetics
,
Medical sciences
,
Middle Aged
,
Molecular modelling
,
MYB NFIB
,
MYB protein
,
Nucleotide sequence
,
Oncogene Proteins
,
Oncogene Proteins, Fusion - genetics
,
Oncogenes
,
Pair 6/genetics
,
Pair 9/genetics
,
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
,
Polymerase chain reaction
,
Proto-Oncogene Proteins c-myb - metabolism
,
Reverse Transcriptase Polymerase Chain Reaction - methods
,
Salivary gland
,
Salivary Gland Neoplasms - metabolism
,
Skin
,
Skin Neoplasms - genetics
,
Skin Neoplasms - metabolism
,
Skin Neoplasms - pathology
,
Skin Neoplasms/genetics/metabolism/pathology
,
Transcription factors
,
Translocation
,
Translocation, Genetic
,
Tumors
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