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Considerations in the developability of peptides for oral administration when formulated together with transient permeation enhancers
Ist Teil von
International journal of pharmaceutics, 2022-11, Vol.628, p.122238-122238, Article 122238
Ort / Verlag
Elsevier B.V
Erscheinungsjahr
2022
Link zum Volltext
Quelle
Elsevier ScienceDirect Journals
Beschreibungen/Notizen
[Display omitted]
This paper reviews many of the properties of a peptide that need to be considered prior to development as an oral dosage form when co-formulated with a permeation enhancer to improve oral bioavailability, including the importance and implications of peptide half-life on variability in pharmacokinetic profiles. Clinical considerations in terms of food and drug-drug interactions are also discussed. The paper further gives a brief overview how permeation enhancers overcome barriers that limit oral absorption of peptides and thereby improve their oral bioavailability, albeit bioavailabilities are still low single digit and variability is high.