Details

Autor(en) / Beteiligte

• Marklund, Matti
• Pingel, Ronnie
• Rosqvist, Fredrik
• Lindroos, Anna Karin
• Eriksson, Jan
• Vessby, Bengt
• Oscarsson, Jan
• Lind, Lars
• Risérus, Ulf

Titel

INTERRELATIONSHIPS BETWEEN FATTY ACID COMPOSITION IN PLASMA CHOLESTEROL ESTERS AND PHOSPHOLIPIDS IN MEN AND WOMEN - A POOLED ANALYSIS

Ist Teil von

• Annals of nutrition and metabolism, 2017-10, Vol.71, p.372

Ort / Verlag

Basel: S. Karger AG

Erscheinungsjahr

2017

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Background and objectives: Fatty acid (FA) proportions in cholesterol esters (CE) and phospholipids (PL) are widely used as biomarkers of dietary fat quality. Information on how proportions in these fractions correlate could have implications for interpretation and use of FA biomarkers in observational and interventional studies. The objectives of this study were to investigate correlations between FA proportions in CE and PL among free-living individuals and to assess how diet-induced alterations of FA proportions correlate between fractions. Methods: Spearman's rank correlation coefficients (rs) between FA proportions (% of total FA) in circulating CE and PL were calculated separately in 8 individual study populations (total n=2052) and pooled by inverse-variance weighted meta-analysis. Additionally, each study population was stratified by age, sex, BMI, and type 2 diabetes status and strata-specific rs were pooled by meta-analysis. Furthermore, rs between FA changes in CE and PL during isocaloric dietary interventions were calculated separately per treatment in two randomized controlled trials (total n=79). Results: Overall, FA proportions in CE and PL ranked individuals similarly. Polyunsaturated FA proportions correlated especially strongly between fractions, with pooled rs (95% CI) ranging from 0.74 (0.72; 0.76) for α-linolenic acid to 0.92 (0.91; 0.93) for eicosapentaenoic acid. Weak correlations (pooled rs< 0.4) were only observed for, palmitic acid and stearic acid, with pooled rs (95% CI): 0.29 (0.24; 0.33) and 0.30 (0.26; 0.34), respectively. Correlations were not evidently affected by age, sex, BMI, or type 2 diabetes. Strong correlations (rs≥ 0.6) between diet-induced FA changes in CE and PL were observed for most PUFA and especially eicosapentaenoic acid , where rs ranged 0.85-0.94 after different treatments. Conclusions: Correlations between FA proportions in CE and PL were generally strong, suggesting that FA proportions in these fractions can be used interchangeably in diverse populations. However, caution is advised when comparing results from studies assessing palmitic acid or stearic acid in different lipid fractions.