Details

Autor(en) / Beteiligte

• Schumann, Gunter
• Liu, Chunyu
• O’Reilly, Paul
• Gao, He
• Song, Parkyong
• Xu, Bing
• Jia, Tianye
• Preis, Sarah
• Lepe, Marcelo Segura
• Akira, Shizuo
• Barbieri, Caterina
• Cauchi, Stephane
• Clarke, Toni-Kim
• Enroth, Stefan
• Fische, Kristar
• Harris, Sarah E.
• Hofer, Edith
• Hottenga, Jouke-Jan
• Joshi, Peter K.
• Kaartinen, Niina
• Lemaitre, Rozenn
• Luan, Jian’an
• Lyytikäinen, Leo-Pekka
• Manichaikul, Ani
• Mbarek, Hamdi
• Milaneschi, Yuri
• Moayyeri, Alireza
• Mukamal, Kenneth
• Nelson, Christopher
• Nettleton, Jennifer
• Partinen, Eemil
• Rawal, Rajesh
• Robino, Antonietta
• Rose, Lynda
• Sala, Cinzia
• Scott, Robert
• Smith, Albert Vernon
• Starr, John M.
• Teumer, Alexander
• Trompet, Stella
• Uitterlinden, André G.
• Venturini, Cristina
• Vergnaud, Anne-Claire
• Verweij, Niek
• Vitart, Veronique
• Vuckovic, Dragana
• Wedenoja, Juho
• Yengo, Loic
• Yu, Bing
• Zhang, Weihua
• Boomsma, Dorret I.
• Chambers, John
• Chasman, Daniel I.
• Daniela, Toniolo
• Deary, Ian
• Eriksson, Johan G.
• Esko, Tõnu
• Eulenburg, Volker
• Froguel, Philippe
• Gieger, Christian
• Grabe, Hans J.
• Gudnason, Vilmundur
• Harris, Tamara B.
• Hartikainen, Anna-Liisa
• Heath, Andrew C.
• Hocking, Lynne
• Hofman, Albert
• Jarvelin, Marjo-Riitta
• Jukema, J. Wouter
• Kaprio, Jaakko
• Kooner, Jaspal S.
• Kutalik, Zoltan
• Liu, Yongmei
• Madden, Pamela A. F.
• Morrison, Alanna
• Pirastu, Nicola
• Psaty, Bruce
• Raitakari, Olli
• Ridker, Paul
• Samani, Nilesh J.
• Schmidt, Helena
• Spector, Tim D.
• Strachan, David
• Tzoulaki, Ioanna
• van Duijn, Cornelia M.
• Marques-Vidal, Pedro
• Vollenweider, Peter
• Wareham, Nicholas J.
• Whitfield, John B.
• Wilson, James
• Wolffenbuttel, Bruce
• Bakalkin, Georgy
• Evangelou, Evangelos
• Liu, Yun
• Rice, Kenneth M.
• Desrivières, Sylvane
• Kliewer, Steven A.
• Mangelsdorf, David J.
• Müller, Christian P.
• Elliott, Paul

Titel

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 2016-12, Vol.113 (50), p.14372-14377

Ort / Verlag

United States: National Academy of Sciences

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Excessive alcohol consumption is a major public health problem worldwide. Although drinking habits are known to be inherited, few genes have been identified that are robustly linked to alcohol drinking. We conducted a genome-wide association metaanalysis and replication study among >105,000 individuals of European ancestry and identified β-Klotho (KLB) as a locus associated with alcohol consumption (rs11940694; P = 9.2 × 10−12). β-Klotho is an obligate coreceptor for the hormone FGF21, which is secreted from the liver and implicated in macronutrient preference in humans. We show that brain-specific β-Klotho KO mice have an increased alcohol preference and that FGF21 inhibits alcohol drinking by acting on the brain. These data suggest that a liver–brain endocrine axis may play an important role in the regulation of alcohol drinking behavior and provide a unique pharmacologic target for reducing alcohol consumption.