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A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk
Cancer research (Chicago, Ill.), 2016-04, Vol.76 (8), p.2288-2300
Travis, Ruth C
Appleby, Paul N
Martin, Richard M
Holly, Jeff M P
Albanes, Demetrius
Black, Amanda
Bueno-de-Mesquita, H B As
Chan, June M
Chen, Chu
Chirlaque, Maria-Dolores
Cook, Michael B
Deschasaux, Mélanie
Donovan, Jenny L
Ferrucci, Luigi
Galan, Pilar
Giles, Graham G
Giovannucci, Edward L
Gunter, Marc J
Habel, Laurel A
Hamdy, Freddie C
Helzlsouer, Kathy J
Hercberg, Serge
Hoover, Robert N
Janssen, Joseph A M J L
Kaaks, Rudolf
Kubo, Tatsuhiko
Le Marchand, Loic
Metter, E Jeffrey
Mikami, Kazuya
Morris, Joan K
Neal, David E
Neuhouser, Marian L
Ozasa, Kotaro
Palli, Domenico
Platz, Elizabeth A
Pollak, Michael
Price, Alison J
Roobol, Monique J
Schaefer, Catherine
Schenk, Jeannette M
Severi, Gianluca
Stampfer, Meir J
Stattin, Pär
Tamakoshi, Akiko
Tangen, Catherine M
Touvier, Mathilde
Wald, Nicholas J
Weiss, Noel S
Ziegler, Regina G
Key, Timothy J
Allen, Naomi E
2016
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Travis, Ruth C
Appleby, Paul N
Martin, Richard M
Holly, Jeff M P
Albanes, Demetrius
Black, Amanda
Bueno-de-Mesquita, H B As
Chan, June M
Chen, Chu
Chirlaque, Maria-Dolores
Cook, Michael B
Deschasaux, Mélanie
Donovan, Jenny L
Ferrucci, Luigi
Galan, Pilar
Giles, Graham G
Giovannucci, Edward L
Gunter, Marc J
Habel, Laurel A
Hamdy, Freddie C
Helzlsouer, Kathy J
Hercberg, Serge
Hoover, Robert N
Janssen, Joseph A M J L
Kaaks, Rudolf
Kubo, Tatsuhiko
Le Marchand, Loic
Metter, E Jeffrey
Mikami, Kazuya
Morris, Joan K
Neal, David E
Neuhouser, Marian L
Ozasa, Kotaro
Palli, Domenico
Platz, Elizabeth A
Pollak, Michael
Price, Alison J
Roobol, Monique J
Schaefer, Catherine
Schenk, Jeannette M
Severi, Gianluca
Stampfer, Meir J
Stattin, Pär
Tamakoshi, Akiko
Tangen, Catherine M
Touvier, Mathilde
Wald, Nicholas J
Weiss, Noel S
Ziegler, Regina G
Key, Timothy J
Allen, Naomi E
Titel
A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk
Ist Teil von
Cancer research (Chicago, Ill.), 2016-04, Vol.76 (8), p.2288-2300
Ort / Verlag
United States: American Association for Cancer Research
Erscheinungsjahr
2016
Quelle
Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
Beschreibungen/Notizen
The role of insulin-like growth factors (IGF) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3) and prostate cancer risk, we pooled individual participant data from 17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 control participants. Conditional logistic regression was used to estimate the ORs for prostate cancer based on the study-specific fifth of each analyte. Overall, IGF-I, IGF-II, IGFBP-2, and IGFBP-3 concentrations were positively associated with prostate cancer risk (Ptrend all ≤ 0.005), and IGFBP-1 was inversely associated weakly with risk (Ptrend = 0.05). However, heterogeneity between the prospective and cross-sectional studies was evident (Pheterogeneity = 0.03), unless the analyses were restricted to prospective studies (with the exception of IGF-II, Pheterogeneity = 0.02). For prospective studies, the OR for men in the highest versus the lowest fifth of each analyte was 1.29 (95% confidence interval, 1.16-1.43) for IGF-I, 0.81 (0.68-0.96) for IGFBP-1, and 1.25 (1.12-1.40) for IGFBP-3. These associations did not differ significantly by time-to-diagnosis or tumor stage or grade. After mutual adjustment for each of the other analytes, only IGF-I remained associated with risk. Our collaborative study represents the largest pooled analysis of the relationship between prostate cancer risk and circulating concentrations of IGF-I, providing strong evidence that IGF-I is highly likely to be involved in prostate cancer development. Cancer Res; 76(8); 2288-300. ©2016 AACR.
Sprache
Englisch
Identifikatoren
ISSN: 0008-5472, 1538-7445
eISSN: 1538-7445
DOI: 10.1158/0008-5472.CAN-15-1551
Titel-ID: cdi_swepub_primary_oai_DiVA_org_uu_296855
Format
–
Schlagworte
Aged
,
Cross-Sectional Studies
,
Food and Nutrition
,
Humans
,
IGF
,
Insulin-Like Growth Factor I - metabolism
,
Life Sciences
,
Male
,
Middle Aged
,
Prostatic Neoplasms
,
Prostatic Neoplasms - blood
,
Prostatic Neoplasms - epidemiology
,
Risk Factors
,
Santé publique et épidémiologie
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