Details

Autor(en) / Beteiligte

• Golla, Sandeep SV
• Boellaard, Ronald
• Oikonen, Vesa
• Hoffmann, Anja
• van Berckel, Bart NM
• Windhorst, Albert D
• Virta, Jere
• Haaparanta-Solin, Merja
• Luoto, Pauliina
• Savisto, Nina
• Solin, Olof
• Valencia, Ray
• Thiele, Andrea
• Eriksson, Jonas
• Schuit, Robert C
• Lammertsma, Adriaan A
• Rinne, Juha O

Titel

Quantification of [18F]DPA-714 Binding in the Human Brain: Initial Studies in Healthy Controls and Alzheimer'S Disease Patients

Ist Teil von

• Journal of cerebral blood flow and metabolism, 2015-05, Vol.35 (5), p.766-772

Ort / Verlag

London, England: SAGE Publications

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Fluorine-18 labelled N,N-diethyl-2-(2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-α]pyrimidine-3-yl)acetamide ([18F] DPA-714) binds to the 18-kDa translocator protein (TSPO) with high affinity. The aim of this initial methodological study was to develop a plasma input tracer kinetic model for quantification of [18F]DPA-714 binding in healthy subjects and Alzheimer's disease (AD) patients, and to provide a preliminary assessment whether there is a disease-related signal. Ten AD patients and six healthy subjects underwent a dynamic positron emission tomography (PET) study along with arterial sampling and a scan protocol of 150 minutes after administration of 250 ± 10 MBq [18F]DPA-714. The model that provided the best fits to tissue time activity curves (TACs) was selected based on Akaike Information Criterion and F-test. The reversible two tissue compartment plasma input model with blood volume parameter was the preferred model for quantification of [18F]DPA-714 kinetics, irrespective of scan duration, volume of interest, and underlying volume of distribution (VT). Simplified reference tissue model (SRTM)-derived binding potential (BPND) using cerebellar gray matter as reference tissue correlated well with plasma input-based distribution volume ratio (DVR). These data suggest that [18F]DPA-714 cannot be used for separating individual AD patients from heathy subjects, but further studies including TSPO binding status are needed to substantiate these findings.