Details

Autor(en) / Beteiligte

• BAROSI, G
• BESSES, C
• HASSELBALCH, H
• LENGFELDER, E
• REILLY, J. T
• MICHIELS, J. J
• BARBUI, T
• BIRGEGARD, G
• BRIERE, J
• CERVANTES, F
• FINAZZI, G
• GISSLINGER, H
• GRIESSHAMMER, M
• GUGLIOTTA, L
• HARRISON, C

Titel

A unified definition of clinical resistance intolerance to hydroxyurea in essential thrombocythemia: results of a consensus process by an international working group

Ist Teil von

• Leukemia, 2007-02, Vol.21 (2), p.277-280

Ort / Verlag

London: Nature Publishing

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• A widely accepted definition of resistance or intolerance to hydroxyurea (HU) in patients with essential thrombocythemia (ET) is lacking. An international working group (WG) was convened to develop a consensus formulation of clinically significant criteria for defining resistance/intolerance to HU in ET. To this aim, an analytic hierarchy process (AHP), a multiple-attribute decision-making technique, was used. The steps consisted of selecting the candidate criteria for defining resistance/intolerance; identifying the motivations that could influence the preference of the WG for any individual criterion; comparing the candidate criteria in a pair-wise manner; and grading them according their ability to fulfill the motivations. Every step in the model was derived by questionnaires or group discussion. The WG proposed that the definition of resistance/intolerance should require the fulfillment of at least one of the following criteria: platelet count greater than 600,000/micro l after 3 months of at least 2 g/day of HU (2.5 g/day in patients with a body weight over 80 kg); platelet count greater than 400,000/micro l and WBC less than 2500/micro l or Hb less than 10 g/dl at any dose of HU; presence of leg ulcers or other unacceptable muco-cutaneous manifestations at any dose of HU; HU-related fever.