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Safety and immunogenicity of three different formulations of an adjuvanted varicella-zoster virus subunit candidate vaccine in older adults: A phase II, randomized, controlled study
Vaccine, 2014-03, Vol.32 (15), p.1745-1753
2014

Details

Autor(en) / Beteiligte
Titel
Safety and immunogenicity of three different formulations of an adjuvanted varicella-zoster virus subunit candidate vaccine in older adults: A phase II, randomized, controlled study
Ist Teil von
  • Vaccine, 2014-03, Vol.32 (15), p.1745-1753
Ort / Verlag
Kidlington: Elsevier Ltd
Erscheinungsjahr
2014
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
  • Highlights • We investigated a herpes zoster vaccine candidate at different antigen doses, and with or without the AS01B Adjuvant System. • All adjuvanted vaccine formulations were immunogenic and well-tolerated in adults ≥60 years of age. • Two vaccinations with the adjuvanted vaccine candidate induced a greater immune response than one. • The dose of varicella-zoster virus glycoprotein E impacted humoral but not cellular immune responses.
Sprache
Englisch
Identifikatoren
ISSN: 0264-410X, 1873-2518
eISSN: 1873-2518
DOI: 10.1016/j.vaccine.2014.01.019
Titel-ID: cdi_swepub_primary_oai_DiVA_org_uu_224365
Format
–
Schlagworte
Adjuvant, Adjuvants, Immunologic - administration & dosage, Age, Aged, Allergy and Immunology, Antibodies, Viral - blood, Applied microbiology, Biological and medical sciences, CD4-Positive T-Lymphocytes - immunology, Dose-Response Relationship, Immunologic, Female, Fundamental and applied biological sciences. Psychology, Herpes zoster, Herpes Zoster Vaccine - adverse effects, Herpes Zoster Vaccine - immunology, Herpes Zoster Vaccine - therapeutic use, Human viral diseases, Humans, Immunity, Cellular, Immunity, Humoral, Immunization Schedule, Infectious diseases, Male, Medical sciences, Microbiology, Middle Aged, Miscellaneous, Older people, Pain, Single-Blind Method, Vaccine, Vaccines, Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects), Vaccines, Subunit - adverse effects, Vaccines, Subunit - immunology, Vaccines, Subunit - therapeutic use, Varicella-zoster virus, Viral diseases, Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye, Virology

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