Details

Autor(en) / Beteiligte

• Schlebusch, Carina M.
• Skoglund, Pontus
• Sjödin, Per
• Gattepaille, Lucie M.
• Hernandez, Dena
• Jay, Flora
• Li, Sen
• De Jongh, Michael
• Singleton, Andrew
• Blum, Michael G. B.
• Soodyall, Himla
• Jakobsson, Mattias

Titel

Genomic Variation in Seven Khoe-San Groups Reveals Adaptation and Complex African History

Ist Teil von

• Science (American Association for the Advancement of Science), 2012-10, Vol.338 (6105), p.374-379

Ort / Verlag

Washington, DC: American Association for the Advancement of Science

Erscheinungsjahr

2012

Quelle

American Association for the Advancement of Science

Beschreibungen/Notizen

• The history of click-speaking Khoe-San, and African populations in general, remains poorly understood. We genotyped ~2.3 million single-nucleotide polymorphisms in 220 southern Africans and found that the Khoe-San diverged from other populations ≥100,000 years ago, but population structure within the Khoe-San dated back to about 35,000 years ago. Genetic variation in various sub-Saharan populations did not localize the origin of modern humans to a single geographic region within Africa; instead, it indicated a history of admixture and stratification. We found evidence of adaptation targeting muscle function and immune response; potential adaptive introgression of protection from ultraviolet light; and selection predating modern human diversification, involving skeletal and neurological development. These new findings illustrate the importance of African genomic diversity in understanding human evolutionary history.