Details

Autor(en) / Beteiligte

• Zody, Michael C
• Nusbaum, Chad
• Garber, Manuel
• Sharpe, Ted
• Young, Sarah K
• Rowen, Lee
• O'Neill, Keith
• Whittaker, Charles A
• Kamal, Michael
• Chang, Jean L
• Cuomo, Christina A
• Dewar, Ken
• FitzGerald, Michael G
• Kodira, Chinnappa D
• Madan, Anup
• Qin, Shizhen
• Yang, Xiaoping
• Abbasi, Nissa
• Abouelleil, Amr
• Arachchi, Harindra M
• Baradarani, Lida
• Birditt, Brian
• Bloom, Scott
• Bloom, Toby
• Borowsky, Mark L
• Burke, Jeremy
• Butler, Jonathan
• Cook, April
• DeArellano, Kurt
• DeCaprio, David
• Dorris, Lester
• Dors, Monica
• Eichler, Evan E
• Engels, Reinhard
• Fahey, Jessica
• Fleetwood, Peter
• Friedman, Cynthia
• Gearin, Gary
• Hall, Jennifer L
• Hensley, Grace
• Johnson, Ericka
• Jones, Charlien
• Kamat, Asha
• Kaur, Amardeep
• Locke, Devin P
• Madan, Anuradha
• Munson, Glen
• Jaffe, David B
• Lui, Annie
• Macdonald, Pendexter
• Mauceli, Evan
• Naylor, Jerome W
• Nesbitt, Ryan
• Nicol, Robert
• O'Leary, Sinéad B
• Ratcliffe, Amber
• Rounsley, Steven
• She, Xinwei
• Sneddon, Katherine M. B
• Stewart, Sandra
• Sougnez, Carrie
• Stone, Sabrina M
• Topham, Kerri
• Vincent, Dascena
• Wang, Shunguang
• Zimmer, Andrew R
• Birren, Bruce W
• Hood, Leroy
• Lander, Eric S

Titel

Analysis of the DNA sequence and duplication history of human chromosome 15

Ist Teil von

• Nature, 2006-03, Vol.440 (7084), p.671-675

Ort / Verlag

London: Nature Publishing

Erscheinungsjahr

2006

Quelle

EBSCOhost Psychology and Behavioral Sciences Collection

Beschreibungen/Notizen

• Here we present a finished sequence of human chromosome 15, together with a high-quality gene catalogue. As chromosome 15 is one of seven human chromosomes with a high rate of segmental duplication, we have carried out a detailed analysis of the duplication structure of the chromosome. Segmental duplications in chromosome 15 are largely clustered in two regions, on proximal and distal 15q; the proximal region is notable because recombination among the segmental duplications can result in deletions causing Prader-Willi and Angelman syndromes. Sequence analysis shows that the proximal and distal regions of 15q share extensive ancient similarity. Using a simple approach, we have been able to reconstruct many of the events by which the current duplication structure arose. We find that most of the intrachromosomal duplications seem to share a common ancestry. Finally, we demonstrate that some remaining gaps in the genome sequence are probably due to structural polymorphisms between haplotypes; this may explain a significant fraction of the gaps remaining in the human genome.