Details

Autor(en) / Beteiligte

• Chabrier, Amelie
• Foretova, Lenka
• Goodman, Gary
• Elvestad, Maiken Bratt
• Matsuda, Fumihiko
• Boffetta, Paolo
• Krokan, Hans E
• Brennan, Paul
• Foglio, Mario
• Hung, Rayjean J
• Njølstad, Inger
• Lubiñski, Jan
• Blanche, Helene
• Montpetit, Alexandre
• Byrnes, Graham
• Lathrop, Mark
• McKay, James D
• Skorpen, Frank
• Delepine, Marc
• Liloglou, Triantafillos
• Chen, Chu
• Field, John
• Lissowska, Jolanta
• Zelenika, Diana
• Gut, Ivo
• Lener, Marcin
• Janout, Vladimir
• McLaughlin, John
• Mukeria, Anush
• Zaridze, David
• Barnett, Matt
• Mates, Dana
• Matyjasik, Joanna
• Rudnai, Peter
• Lechner, Doris
• Heath, Simon
• Cassidy, Adrian
• Oszutowska, Dorota
• Shepherd, Frances
• Bencko, Vladimir
• Gaborieau, Valerie
• Szeszenia-Dabrowska, Neonilia
• Xinarianos, George
• Vatten, Lars
• Narod, Steven
• Loomis, Melissa M
• Fabianova, Eleonora
• Axelsson, Tomas
• Boland, Anne

Titel

Lung cancer susceptibility locus at 5p15.33

Ist Teil von

• Nature genetics, 2008-12, Vol.40 (12), p.1404-1406

Ort / Verlag

United States: Nature Publishing Group

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease markers at 5p15.33, rs402710 and rs2736100 were detected by the genome-wide data (P = 2 × 10−7 and P = 4 × 10−6) and replicated by the independent study series (P = 7 × 10−5 and P = 0.016). The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology.