Vaccine, 2013-12, Vol.31 (51), p.6136-6143
2013
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Details
- Autor(en) / Beteiligte
- Titel
- Safety and immunogenicity of a glycoprotein D genital herpes vaccine in healthy girls 10–17 years of age: Results from a randomised, controlled, double-blind trial
- Ist Teil von
- Vaccine, 2013-12, Vol.31 (51), p.6136-6143
- Ort / Verlag
- Kidlington: Elsevier Ltd
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • We evaluated safety of an investigational HSV vaccine in girls aged 10–17 years. • Serious adverse events (SAEs) were evaluated over 12 months (primary objective). • SAE rates did not differ significantly between the HSV vaccine and control groups. • A clinically acceptable safety profile was observed for the HSV vaccine overall. • The HSV vaccine was immunogenic in this study group, regardless of HSV serostatus.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0264-410X, 1873-2518eISSN: 1873-2518DOI: 10.1016/j.vaccine.2013.06.081Titel-ID: cdi_swepub_primary_oai_DiVA_org_umu_88302
- Format
- –
- Schlagworte
- Adolescent, adolescents, adults, Allergy and Immunology, Applied microbiology, Biological and medical sciences, Child, Chronic illnesses, Confidence intervals, Consent, Disease, Double-Blind Method, Drug therapy, Drug-Related Side Effects and Adverse Reactions - epidemiology, Drug-Related Side Effects and Adverse Reactions - pathology, Female, Fundamental and applied biological sciences. Psychology, Genital herpes, girls, glycoproteins, Hepatitis, Hepatitis A virus, Herpes Genitalis - immunology, Herpes Genitalis - prevention & control, Herpes simplex virus 1, Herpes simplex virus 2, Herpes simplex virus type 1, Herpes simplex virus type 2, Herpesvirus 2, Human - immunology, Herpesvirus Vaccines - administration & dosage, Herpesvirus Vaccines - adverse effects, Herpesvirus Vaccines - immunology, HSV vaccine, Human herpesvirus 2, human resources, Humans, immune response, Infections, MEDICIN, MEDICINE, Microbiology, Miscellaneous, Placebos - administration & dosage, Safety, seroprevalence, Vaccines, Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects), Vaccines, Subunit - administration & dosage, Vaccines, Subunit - adverse effects, Vaccines, Subunit - immunology, Viral Envelope Proteins - immunology, Virology, Womens health