Details

Autor(en) / Beteiligte

• Patterson, Christopher C.
• Harjutsalo, Valma
• Rosenbauer, Joachim
• Neu, Andreas
• Cinek, Ondrej
• Skrivarhaug, Torild
• Rami-Merhar, Birgit
• Soltesz, Gyula
• Svensson, Jannet
• Parslow, Roger C.
• Castell, Conxa
• Schoenle, Eugen J.
• Bingley, Polly J.
• Dahlquist, Gisela
• Jarosz-Chobot, Przemyslawa K.
• Marciulionyte, Dale
• Roche, Edna F.
• Rothe, Ulrike
• Bratina, Natasa
• Ionescu-Tirgoviste, Constantin
• Weets, Ilse
• Kocova, Mirjana
• Cherubini, Valentino
• Putarek, Natasa Rojnic
• Debeaufort, Carine E.
• Samardzic, Mira
• Green, Anders

Titel

Trends and cyclical variation in the incidence of childhood type 1 diabetes in 26 European centres in the 25year period 1989-2013: a multicentre prospective registration study

Ist Teil von

• Diabetologia, 2019-03, Vol.62 (3), p.408

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Aims/hypothesis: Against a background of a near-universally increasing incidence of childhood type 1 diabetes, recent reports from some countries suggest a slowing in this increase. Occasional reports also describe cyclical variations in incidence, with periodicities of between 4 and 6years. Methods: Age/sex-standardised incidence rates for the 0- to 14-year-old age group are reported for 26 European centres (representing 22 countries) that have registered newly diagnosed individuals in geographically defined regions for up to 25years during the period 1989-2013. Poisson regression was used to estimate rates of increase and test for cyclical patterns. Joinpoint regression software was used to fit segmented log-linear relationships to incidence trends. Results: Significant increases in incidence were noted in all but two small centres, with a maximum rate of increase of 6.6% per annum in a Polish centre. Several centres in high-incidence countries showed reducing rates of increase in more recent years. Despite this, a pooled analysis across all centres revealed a 3.4% (95% CI 2.8%, 3.9%) per annum increase in incidence rate, although there was some suggestion of a reduced rate of increase in the 2004-2008 period. Rates of increase were similar in boys and girls in the 0- to 4-year-old age group (3.7% and 3.7% per annum, respectively) and in the 5- to 9-year-old age group (3.4% and 3.7% per annum, respectively), but were higher in boys than girls in the 10- to 14-year-old age group (3.3% and 2.6% per annum, respectively). Significant 4year periodicity was detected in four centres, with three centres showing that the most recent peak in fitted rates occurred in 2012. Conclusions/interpretation: Despite reductions in the rate of increase in some high-risk countries, the pooled estimate across centres continues to show a 3.4% increase per annum in incidence rate, suggesting a doubling in incidence rate within approximately 20years in Europe. Although four centres showed support for a cyclical pattern of incidence with a 4year periodicity, no plausible explanation for this can be given.