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Hemochromatosis gene mutations among Finnish male breast and prostate cancer patients
International journal of cancer, 2006-01, Vol.118 (2), p.518-520
Syrjäkoski, Kirsi
Fredriksson, Henna
Ikonen, Tarja
Kuukasjärvi, Tuula
Autio, Ville
Matikainen, Mika P.
Tammela, Teuvo L.J.
Koivisto, Pasi A.
Schleutker, Johanna
2006
Details
Autor(en) / Beteiligte
Syrjäkoski, Kirsi
Fredriksson, Henna
Ikonen, Tarja
Kuukasjärvi, Tuula
Autio, Ville
Matikainen, Mika P.
Tammela, Teuvo L.J.
Koivisto, Pasi A.
Schleutker, Johanna
Titel
Hemochromatosis gene mutations among Finnish male breast and prostate cancer patients
Ist Teil von
International journal of cancer, 2006-01, Vol.118 (2), p.518-520
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2006
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
Hereditary hemochromatosis (HH), the most common genetic disease in northern Europeans, is an autosomal recessive disorder of iron metabolism. The association between hepatocellular carcinoma and HFE homozygosity is well documented, but recently HFE hetero‐ and homozygosity has also been linked to nonhepatocellular malignancies, including female breast cancer. We hypothesized that C282Y and H63D mutations in the HFE gene could contribute to male breast cancer (MBC) and prostate cancer (PC) susceptibility at the population level in Finland. We screened the 2 major HFE mutations, H63D and C282Y, from 116 MBC cases diagnosed in Finland between 1967 and 1996, 843 consecutive unselected PC cases diagnosed at the Pirkanmaa Hospital District between 1999 and 2001 and 480 anonymous blood donor controls by minisequencing. Our results indicate that the frequencies of the HFE mutations do not significantly differ between MBC and PC patients and the population‐based controls. No significantly altered risks for MBC or PC among carriers of the 2 variants were observed. However, HFE mutations were seen twice as often among carriers of a common BRCA2 mutation 9346(−2)A→G compared with the rest of the MBC cases, indicating that HFE may be an MBC risk modifier gene among BRCA2 mutation carriers. In conclusion, our results indicate a minor role for the HFE mutations C282Y and H63D in the causation of MBC and PC, but carriers of both BRCA2 9346(−2)A→G and an HFE mutation may be at an increased risk. © 2005 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0020-7136
eISSN: 1097-0215
DOI: 10.1002/ijc.21331
Titel-ID: cdi_swepub_primary_oai_DiVA_org_umu_15301
Format
–
Schlagworte
Aged
,
Aged, 80 and over
,
Biological and medical sciences
,
Breast Neoplasms, Male - genetics
,
C282Y
,
Case-Control Studies
,
DNA Mutational Analysis
,
Female
,
Finland
,
Genetic Predisposition to Disease
,
Gynecology. Andrology. Obstetrics
,
H63D
,
Hemochromatosis Protein
,
hereditary hemochromatosis
,
Histocompatibility Antigens Class I - genetics
,
Humans
,
Male
,
male breast cancer
,
Mammary gland diseases
,
Medical sciences
,
Membrane Proteins - genetics
,
Middle Aged
,
prostate cancer
,
Prostatic Neoplasms - genetics
,
Risk Factors
,
Tumors
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