Details

Autor(en) / Beteiligte

• Bornschein, Christoph
• Gustafson, Karl P. J.
• Verho, Oscar
• Beller, Matthias
• Bäckvall, Jan-E.

Titel

Evaluation of Fe and Ru Pincer-Type Complexes as Catalysts for the Racemization of Secondary Benzylic Alcohols

Ist Teil von

• Chemistry : a European journal, 2016-08, Vol.22 (33), p.11583-11586

Ort / Verlag

Germany: Blackwell Publishing Ltd

Erscheinungsjahr

2016

Quelle

Wiley Online Library Journals【Remote access available】

Beschreibungen/Notizen

• Fe and Ru pincer‐type catalysts are used for the racemization of benzylic alcohols. Racemization with the Fe catalyst was achieved within 30 minutes under mild reaction conditions, with a catalyst loading as low as 2 mol %. This reaction constitutes the first example of an iron‐catalyzed racemization of an alcohol. The efficiency for racemization of the Fe catalyst and its Ru analogue was evaluated for a wide range of sec‐benzylic alcohols. The commercially available Ru complex proved to be highly robust and even tolerated the presence of water in the reaction mixture. Alcohols racemize with iron: The first Fe‐catalyzed protocol for the racemization of secondary benzylic alcohols using pincer‐type complexes has been developed. The efficiency for racemization of both the Fe catalyst and its Ru analogue was evaluated for a wide range of sec‐benzylic alcohols. It was found that the commercially available Ru complex tolerates water and air in the reaction mixture during racemization.