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BibTeX
In vivo investigation of thiomer–polyvinylpyrrolidon nanoparticles using magnetic resonance imaging
Journal of pharmaceutical sciences, 2010-04, Vol.99 (4), p.2008-2017
Albrecht, K.
Greindl, M.
Deutel, B.
Kremser, C.
Wolf, C.
Talasz, H.
Stollenwerk, M.M.
Debbage, P.
Bernkop‐Schnürch, A.
2010
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Albrecht, K.
Greindl, M.
Deutel, B.
Kremser, C.
Wolf, C.
Talasz, H.
Stollenwerk, M.M.
Debbage, P.
Bernkop‐Schnürch, A.
Titel
In vivo investigation of thiomer–polyvinylpyrrolidon nanoparticles using magnetic resonance imaging
Ist Teil von
Journal of pharmaceutical sciences, 2010-04, Vol.99 (4), p.2008-2017
Ort / Verlag
Hoboken: Elsevier Inc
Erscheinungsjahr
2010
Quelle
MEDLINE
Beschreibungen/Notizen
This study focused on the investigation of the permeation enhancing effects of a stomach targeted, nanoparticulate drug delivery system. The polyacrylic acid–cysteine/polyvinylpyrrolidon nanoparticles were loaded with the magnetic resonance imaging (MRI) contrast agent diethylenetriaminepentaacetic acid gadolinium(III)dihydrogen salt (Gd‐DTPA). Average particle size was determined to be 130 nm and the optimum for stability was found to be below a pH of 4.5. In vitro permeation studies were performed on rat gastric mucosa and revealed an eightfold increase in Gd‐DTPA uptake when incorporated in the nanoparticles compared to evaluation in the presence of unformulated polyacrylic acid–cysteine. In vivo investigations with rats were performed via the noninvasive MRI method in order to track the nanoparticles way through the gastrointestinal tract. When Gd‐DTPA was administered orally as nanoparticulate suspension, an increased MRI signal in the urinary bladder was detected after 34 min, providing evidence for systemic uptake and renal elimination of the contrast agent. As control experiments with Gd‐DTPA only or in combination with unformulated polyacrylic acid–cysteine revealed no MRI signal increase at all, the significant permeation enhancing effect could be identified based on the nanoparticulate formulation. © 2009 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 99: 2008–2017, 2010
Sprache
Englisch
Identifikatoren
ISSN: 0022-3549, 1520-6017
eISSN: 1520-6017
DOI: 10.1002/jps.21969
Titel-ID: cdi_swepub_primary_oai_DiVA_org_mau_3919
Format
–
Schlagworte
absorption enhancer
,
Acrylic Resins - chemistry
,
Administration, Oral
,
Animals
,
Biological and medical sciences
,
Contrast Media - administration & dosage
,
Contrast Media - pharmacokinetics
,
Cysteine - chemistry
,
Gadolinium DTPA - administration & dosage
,
Gadolinium DTPA - pharmacokinetics
,
Gastric Mucosa - metabolism
,
General pharmacology
,
Kidney - metabolism
,
Magnetic Resonance Imaging - methods
,
Male
,
Medical sciences
,
nanoparticles
,
Nanoparticles - chemistry
,
oral drug delivery
,
Permeability
,
Pharmaceutical technology. Pharmaceutical industry
,
Pharmacology. Drug treatments
,
polymeric drug delivery
,
Povidone - chemistry
,
Rats
,
Rats, Sprague-Dawley
,
renal excretion
,
Urinary Bladder - metabolism
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