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Initial Use of Ambrisentan plus Tadalafil in Pulmonary Arterial Hypertension
Ist Teil von
The New England journal of medicine, 2015-08, Vol.373 (9), p.834-844
Ort / Verlag
United States: Massachusetts Medical Society
Erscheinungsjahr
2015
Quelle
MEDLINE
Beschreibungen/Notizen
Patients with previously untreated pulmonary arterial hypertension who were randomly assigned to combination therapy with ambrisentan and tadalafil had a significantly lower risk of a composite clinical failure outcome at 20 months than did the pooled monotherapy group.
Regardless of the initiating trigger, pulmonary arterial hypertension results in the altered synthesis of a variety of vasoactive substances derived from the endothelium.
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Current therapies for pulmonary arterial hypertension
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target abnormalities in one of three intracellular pathways with signaling dysfunction: the prostacyclin, nitric oxide, or endothelin pathway.
1
However, no single class of drug is consistently effective in treating all patients, which suggests that no single pathway plays a dominant pathogenic role.
3
,
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Combination therapy with agents that target several different pathways may potentially increase the overall therapeutic effect on the mechanisms of this disease
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and provide additional clinical benefits.
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– . . .