Details

Autor(en) / Beteiligte

• Darkins, Christopher Luke
• Mandenius, Carl-Fredrik

Titel

Design of large-scale manufacturing of induced pluripotent stem cell derived cardiomyocytes

Ist Teil von

• Chemical engineering research & design, 2014-06, Vol.92 (6), p.1142-1152

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2014

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• •Scale-up of manufacture of cardiomyocytes from pluripotent stem cellsis described.•The use of biomechatronic design methodology in combination with CAD is shown.•User requirement criteria are systematically analyzed for most favourable design. A new approach for design of large-scale manufacture of stem cell derived cells by using the biomechatronic methodology and computer-aided-design tools is described. The systematic conceptual design methodology for systems composed of active mechanical, electronic and biological components, here referred to as biomechatronics, is combined with the methodology for computer-aided design of bioprocesses. The objective has been to systematically investigate and compare by the combination of the methodologies what are favourable design alternatives in terms of equipment configuration and economic parameters. A demonstration case has been used for the manufacture of cardiomyocytes from human induced pluripotent stem cells. The results show how certain configurations are more favourable than others under given boundary conditions. The study indicates that the approach is possible to apply on other related bio-manufacturing systems.