Journal of micromechanics and microengineering, 2002-09, Vol.12 (5), p.682-687, Article 326
2002
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Details
- Autor(en) / Beteiligte
- Titel
- Development of micromachined hollow tips for protein analysis based on nanoelectrospray ionization mass spectrometry
- Ist Teil von
- Journal of micromechanics and microengineering, 2002-09, Vol.12 (5), p.682-687, Article 326
- Ort / Verlag
- Bristol: IOP Publishing
- Erscheinungsjahr
- 2002
- Quelle
- Alma/SFX Local Collection
- Beschreibungen/Notizen
- Two novel types of micromachined nanoelectrospray emitter tips have been designed, fabricated and tested. The fabrication method of the hollow tips is based on a self-aligning deep reactive ion etch process. The tips consist of either silicon dioxide or silicon and feature orifice diameters of 10 and 18 mu m, respectively. The geometrical characteristics of both emitter types are favorable for the generation of stable electrospray ionization, i.e. wetting of the tip shaft is avoided and the base of the Taylor cone is limited to the diameter of the orifice. A silicon dioxide tip was operated in a bench top setup to visually evaluate the electrospray. Both types of tips were also successfully used for the analysis of an insulin sample in an ion trap mass spectrometer.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-1317, 1361-6439eISSN: 1361-6439DOI: 10.1088/0960-1317/12/5/326Titel-ID: cdi_swepub_primary_oai_DiVA_org_kth_21925
- Format
- –
- Schlagworte
- beam, chip, electrospray source, Exact sciences and technology, General equipment and techniques, Geometry, Instruments, apparatus, components and techniques common to several branches of physics and astronomy, ion-source, Mass spectrometers and related techniques, Mass spectrometry, Mechanical instruments, equipment and techniques, microfabricated device, Micromechanical devices and systems, Orifices, Physics, Proteins, Reactive ion etching, Sensors (chemical, optical, electrical, movement, gas, etc.), remote sensing, Silica, Wetting