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Staphylococcal surface display and its applications
Ist Teil von
International journal of medical microbiology, 2000-12, Vol.290 (7), p.571-577
Ort / Verlag
Jena: Elsevier GmbH
Erscheinungsjahr
2000
Link zum Volltext
Quelle
Elsevier ScienceDirect Journals
Beschreibungen/Notizen
Novel surface proteins can be introduced onto the bacterial cell surface by recombinant means. Here, we describe the development of such display systems for two food-grade bacteria,
Staphylococcus carnosus and
Staphylococcus xylosus, and present how such engineered bacteria can be used in different applications. A study will be described in which such staphylococci were employed as vaccine delivery vehicles to elicit protective antibody responses to respiratory syncytial virus (RSV). The use of surface-engineered staphylococci as novel microbial biocatalysts, as a new type of wholecell diagnostic devices or for adsorption of metal ions with potential environmental or biosensor applications, will also be discussed.