Genomics (San Diego, Calif.), 2004-08, Vol.84 (2), p.331-345
2004
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- Autor(en) / Beteiligte
- Titel
- Characterization of the type I interferon locus and identification of novel genes
- Ist Teil von
- Genomics (San Diego, Calif.), 2004-08, Vol.84 (2), p.331-345
- Ort / Verlag
- San Diego, CA: Elsevier Inc
- Erscheinungsjahr
- 2004
- Quelle
- Elsevier ScienceDirect Journals
- Beschreibungen/Notizen
- The human type I interferon (IFN) genes are clustered on human chromosome 9p21 and the mouse genes are located in the region of conserved synteny on mouse chromosome 4. We have identified two novel mouse Ifna genes ( Ifna12, Ifna13) and Ifnl2 (IFN-like 2, a homologue of Limitin/IFN-like 1). Another type I IFN gene was designated Ifne1. Mouse Ifne1 was expressed in ovaries and uterus but not in tissues of hematopoietic origin. IFN-ε1 has general structural characteristics of a type I IFN. These studies represent the first detailed annotation of the mouse type I IFN locus, and the products of these novel genes may have important functions in reproduction and host defense.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0888-7543, 1089-8646eISSN: 1089-8646DOI: 10.1016/j.ygeno.2004.03.003Titel-ID: cdi_swepub_primary_oai_DiVA_org_his_9894
- Format
- –
- Schlagworte
- Amino Acid Sequence, Animals, Base Sequence, Biological and medical sciences, Cell differentiation, maturation, development, hematopoiesis, Cell Line, Cell physiology, Chromosome Mapping, Chromosomes, Human, Pair 9 - genetics, Cloning, Molecular, Embryonic development, Female, Fundamental and applied biological sciences. Psychology, Gene Expression Profiling, Genes. Genome, Genetics of eukaryotes. Biological and molecular evolution, Genomic locus, Human chromosome 9, Humans, Interferon type I, Interferon Type I - chemistry, Interferon Type I - genetics, Medical sciences, Medicin, Mice, Models, Molecular, Molecular and cellular biology, Molecular genetics, Molecular Sequence Data, Mouse chromosome 4, Natural sciences, Naturvetenskap, Ovary - metabolism, Phylogeny, Protein Structure, Secondary, Protein Structure, Tertiary, Pseudogenes - genetics, RNA, Messenger - genetics, RNA, Messenger - metabolism, Sequence Alignment, Uterus - metabolism, Viruses - immunology