Details

Autor(en) / Beteiligte

• Schneider, Lukas
• Larocca, Michele
• Wu, Wenyu
• Babu, Vipin
• Padrutt, Roxane
• Slyshkina, Ekaterina
• König, Christiane
• Ferrari, Stefano
• Spingler, Bernhard

Titel

Exocyclically metallated tetrapyridinoporphyrazine as a potential photosensitizer for photodynamic therapy

Ist Teil von

• Photochemical & photobiological sciences, 2019, Vol.18 (11), p.2792-283

Ort / Verlag

Cham: Springer International Publishing

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Springer journals

Beschreibungen/Notizen

• We report the first exocyclically metallated tetrapyridinoporphyrazine, [tetrakis-( trans -Pt(NH 3 ) 2 Cl)-tetra(3,4-pyrido)porphyrazine-zinc( ii )](NO 3 ) 4 ( 4 ), synthesized in a multistep synthesis starting from 3,4-pyridinedicarbonitrile ( 1 ). The synthetic procedure involved a platination reaction of the intermediate tetra(3,4-pyrido)porphyrazine-zinc( ii ) ( 2 ), whereby the zinc( ii ) enhanced the solubility of the intermediate enabling the platination reaction. A similar approach to synthesize [tetrakis-( trans -Pt(NH 3 ) 2 Cl)-tetra(3,4-pyrido)porphyrazine](NO 3 ) 4 ( 5 ) failed due to the unsuitable solubility properties of the intermediate tetra(3,4-pyrido)porphyrazine ( 3 ). The final product 4 and the intermediates were characterized, the photochemical and photophysical properties were determined and the photocytotoxicities were investigated. We demonstrate that the platinated tetra-pyridinoporphyrazine 4 is a potential photosensitizer for photodynamic therapy (PDT). Synthesis and biological evaluations of a potential dual chemotherapeutic photosensitizer for photodynamic therapy based on the first exocyclically platinated tetrapyridinoporphyrazine.