Details

Autor(en) / Beteiligte

• Brodovskaya, E. P.
• Zaslavskaya, K. Ya
• Ayub, A. M. Al-Haj
• Khutorskaya, I. A.
• Zaborovskii, A. V.
• Tararina, L. A.
• Unina, D. V.
• Sokolov, F. S.
• Radaeva, O. A.
• Balykova, L. A.
• Pyataev, N. A.

Titel

In Vitro Study of the Cytotoxic and Immunotropic Effects of Molnupiravir and Favipiravir

Ist Teil von

• Pharmaceutical chemistry journal, 2024-02, Vol.57 (11), p.1693-1697

Ort / Verlag

New York: Springer US

Erscheinungsjahr

2024

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The effects of the antiviral drugs molnupiravir and favipiravir on the viability of human embryonic lung cells and the production of cytokines by peripheral blood leukocytes of healthy donors and patients with coronavirus infections were studied. Neither molnupiravir nor favipiravir nor their combination at concentrations up to 60 μg/mL was shown to have a significant effect on the survival of human embryonic lung cells. Also, the combination of molnupiravir and favipiravir was shown to decrease the level of both pro-inflammatory (IL-1, TNF) and anti-inflammatory cytokines (IL-10) and did not significantly affect the levels of IL-6 and IFN-α.