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This chapter deals with emerging QDs and NPs that can be utilized as bioimaging probes for cancer nanomedicine. It covers topics on deep-tissue bimodal imaging utilizing NIR emitting QDs and other interesting Au-NPs and tripods for bioimaging and therapy. Drug carriers such as iron oxide NPs, silica-, graphene-, graphene oxide- based nanocarriers, peptides or polymer mediated delivery vehicles, and liposomes for targeted delivery are discussed. Metallic nanostructures and plasmonic bimetallic nanocrystals and core–shell nanocomposites for combined photothermal-/chemo- or radio-/chemo-therapy are delineated.