Details

Autor(en) / Beteiligte

• Inagaki, Masahito
• Wada, Takehiko
• Fox, Keith R.
• Sugimoto, Naoki

Titel

External Stimulation-Responsive Artificial Nucleic Acids: Peptide Ribonucleic Acid (PRNA)-Programmed Assemblies

Ist Teil von

• Handbook of Chemical Biology of Nucleic Acids, p.2747-2772

Ort / Verlag

Singapore: Springer Nature Singapore

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Stimulus-response control of functions, induced by conformational and/or structural changes of nucleic acids and their derivatives, has attracted attention for various applications. Several and diverse triggers such as temperature changes, pH changes, photo-irradiation, etc. have been extensively investigated as non-invasive stimuli to control the functions and properties of target compounds and/or materials. In the fields of functional molecular science and technology of nucleic acids and their derivatives, such as supramolecular and/or nanomaterial systems, typically DNA origami systems, the stimuli-responsive assembly and/or disassembly systems have been actively investigated, and a variety of unique and interesting systems have been reported in the last two decades. In life science-related fields, such as molecular biology and pharmaceutical sciences, chemically modified nucleosides, nucleotides, and oligonucleotides expressing therapeutic activity in a stimuli-responsive manner are considered as robust strategies and tools for the development of effective therapeutic compounds with reduced side effects and toxicity. This chapter focuses on reviewing the life science applications of these chemically modified nucleic acid derivatives, particularly stimulus-responsive derivatives for nucleic acid drugs (oligonucleotide therapeutics).