Details

Autor(en) / Beteiligte

• Fluhr, Joachim W.
• Darlenski, Razvigor

Titel

Skin Barrier

Ist Teil von

• Life-Threatening Dermatoses and Emergencies in Dermatology, p.3-18

Ort / Verlag

Berlin, Heidelberg: Springer Berlin Heidelberg

Link zum Volltext

Beschreibungen/Notizen

• Skin accomplishes the protection of the mammalian organism against exogenous physical, chemical, and biological agents, as well as sustaining the organism's homeostasis.The majority of the barrier mechanisms of the skin are attributed to the stratum corneum.The concept of ‘bricks-and-mortar’ organisation of the stratum corneum comprises the corneocytes with their cornified envelope and the intercellular bilamellar lipids.The regulation of the skin barrier homeostasis involves different mechanisms: skin surface pH, hydration of the stratum corneum, calcium ion gradient in the epidermis, nuclear hormone receptors and their ligands, and immune-cell mediators.The cutaneous barrier is perturbed in skin diseases such as atopic dermatitis, irritant dermatitis, and psoriasis, as well as in certain lifethreatening dermatoses, e.g. toxic epidermal necrolysis, staphylococcal scalded skin syndrome, and Netherton syndrome.Skin barrier function can be assessed by noninvasive methods in vivo, e.g. transepidermal water loss, stratum corneum hydration, and skin surface pH measurement.