Details

Autor(en) / Beteiligte

• Percival, Mary-Elizabeth M.
• Estey, Elihu H.

Titel

Cure of APL Without Chemotherapy

Ist Teil von

• Acute Promyelocytic Leukemia, 2018, p.133-151

Ort / Verlag

Cham: Springer International Publishing

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The chemotherapy-free treatment of acute promyelocytic leukemia (APL) is a modern success story. Early clinical trials in China during the 1980s suggested the potent activity of all-trans retinoic acid (ATRA) in APL, leading to differentiation of the malignant cells and complete remission. In the 1990s, arsenic trioxide (ATO) was also shown to lead to differentiation of the promyelocytes. Thus, the current treatment for newly diagnosed standard-risk APL (white blood cell count <10 × 109 cells/L) in adults is ATRA and ATO without chemotherapy, which leads to a remarkable cure rate of over 90%. In newly diagnosed patients with high-risk APL (white blood cell count ≥10 × 109 cells/L), cytoreduction with gemtuzumab ozogamicin or anthracyclines is recommended in addition to combination ATRA and ATO. A once highly fatal disease has now become the most highly curable subtype of acute myeloid leukemia, in most cases without the need for chemotherapy.