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Secret Life of Tiny Blood Vessels: Lactate, Scaffold and Beyond
Ist Teil von
Bioinformatics and Biomedical Engineering, p.591-601
Ort / Verlag
Cham: Springer International Publishing
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
We studied the model of cerebral angiogenesis in vitro using lactate-releasing gelatin bioscaffolds and primary culture of brain endothelial cells. We found that development of microvessels from actively proliferating rat brain microvessels endothelial cells was greatly modified by the presence of lactate at the surface of the scaffold with different lactate-releasing ability. Fractal dimension of newly-established vessel loops allows precise characterizing the local microenvironment supporting cell growth on various types of gelatin scaffolds.