Details

Autor(en) / Beteiligte

• Pehlivanović Kelle, Belma
• Kurtalić, Lejla
• Šapčanin, Aida
• Bečić, Fahir
• Gurbeta Pokvić, Lejla
• Badnjević, Almir

Titel

Role and Application of Curcumin in Conventional Cancer Therapy

Ist Teil von

• MEDICON’23 and CMBEBIH’23, p.377-382

Ort / Verlag

Cham: Springer Nature Switzerland

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Cancer therapy is the most complex form of therapy, which in clinical practice involves the use of different classes of drugs with insufficient efficiency and pronounced side effects. Therefore, in recent years, the application and effectiveness of a large number of natural compounds on the therapeutic outcome and indications for various types of cancer therapy have been continuously investigated. Curcumin or diferuloylmethane is a bioactive, polyphenolic substance obtained by extraction from the rhizome of the plant Curcuma longa L., Zingiberaceae. It has a wide range of pharmacological activity through different molecular mechanisms and due to proven anti-inflammatory and anti-proliferative activity, special interest is directed toward the use of curcumin in oncology therapy. The aim of this paper is to summarize and critically analyze the collected data on the potential use of curcumin in cancer therapy. Curcumin modulates vital cellular responses such as cell cycle arrest, apoptosis, and cell differentiation, resulting in the activation of cascading molecular processes. Recent studies have shown the ability of curcumin to reduce the proliferation of cancer cells by inducing apoptosis, inhibiting angiogenesis, and reducing the expression of anti-apoptotic proteins. Also, studies in which curcumin was used as an adjuvant in oncology therapy resulted in a reduction in the side effects of therapy caused by the anticancer drugs. It has been proven that the combined use of curcumin with bevacizumab significantly reduces the growth of cancer cells without any recorded side effects. Current findings indicate the great potential of curcumin in the prevention and treatment of cancer and the use of curcumin as a therapeutic supplement in addition to conventional cancer immunotherapy.