Details

Autor(en) / Beteiligte

• Yamaguchi, Yoshiki
• Yamaguchi, Takumi
• Kato, Koichi

Titel

Structural Analysis of Oligosaccharides and Glycoconjugates Using NMR

Ist Teil von

• Glycobiology of the Nervous System, 2023, Vol.29, p.163-184

Ort / Verlag

Switzerland: Springer International Publishing AG

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Carbohydrate chains play critical roles in cellular recognition and subsequent signal transduction in the nervous system. Furthermore, gangliosides are targets for various amyloidogenic proteins associated with neurodegenerative disorders. To better understand the molecular mechanisms underlying these biological phenomena, atomic views are essential to delineate dynamic biomolecular interactions. Nuclear magnetic resonance (NMR) spectroscopy provides powerful tools for studying structures, dynamics, and interactions of biomolecules at the atomic level. This chapter describes the basics of solution NMR techniques and their applications to the analysis of 3D structures and interactions of glycoconjugates in the nervous system.