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This chapter analyzes the living conditions of persons who inject drugs (PWIDs) in Tijuana, a border city in the northern part of Mexico, as an example of the adversities associated with drug use. The social and emotional problems of PWIDs include poverty, restricted access to health-care services, malnourishment, low education, and few job opportunities. In addition, stigma, discrimination, police brutality, traumatic experiences, and sexual violence are also common among opioid users. This chapter seeks to give voice to opioid users through personal narratives, emphasizing the need for a person-centered perspective to address the current opioid crisis effectively. Although most of the data presented here were collected in Tijuana, this chapter also analyzes some differences and commonalities of PWIDs in other parts of the world, through testimonies obtained from the literature.