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Infections of the skin, subcutaneous fat, muscle, and connective tissues include cellulitis, soft tissue abscesses, tenosynovitis, myositis and necrotizing fasciitis. This chapter aims to provide a broad overview of the presentation of these clinical entities in a progressive manner, with a special focus on the management, reconstruction and novel therapies aimed at ameliorating the ravages of soft tissue infections. Despite the significant promise of an emerging panoply of naturally occurring and synthetic materials aimed at improving wound healing, new technologies and advances face the challenges of completing randomized controlled clinical trials to demonstrate efficacy in wound healing. As such, mainstay principles of controlling comorbidities (diabetes, vascular disease, nicotine avoidance, nutrition, etc.) and wound management principles (debridement, infectious control, surgical management of abscesses/necrosis) remain the keystone of wound care.