Details

Autor(en) / Beteiligte

• Arslan, Shukaib
• Khaled, Samer
• Nakamura, Ryotaro
• Pullarkat, Vinod
• Marcucci, Guido

Titel

Current Management and New Developments in the Treatment of Myelodysplastic Syndrome

Ist Teil von

• Biology and Treatment of Leukemia and Bone Marrow Neoplasms, 2021, Vol.181, p.115-132

Ort / Verlag

Switzerland: Springer International Publishing AG

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Myelodysplastic syndrome (MDS) is a heterogeneous hematological neoplasm with a wide range of clinical presentations from isolated anemia to pancytopenia and propensity to transform to acute myeloid leukemia. MDS is characterized by morphologic bone marrow dysplasia and ineffective hematopoiesis resulting from a range of cytogenetic abnormalities and somatic gene mutations. Disease management varies from observation alone for low-risk disease to hypomethylating agents and hematopoietic cell transplantation (HCT) for higher risk disease. In this chapter, we review the classification, risk stratification, and optimal management of patients with MDS.