Details

Autor(en) / Beteiligte

• Srinivas, Sangly P.
• Chaiyasan, Wanachat
• Burli, Anirudh
• Guidoboni, Giovanna
• Sacco, Riccardo
• Anand, Abhishek
• Siraj, Amreen H.
• Daima, Hemant Kumar
• Kompella, Uday B.
• Neervannan, Seshadri

Titel

Transcorneal Kinetics of Topical Drugs and Nanoparticles

Ist Teil von

• Ophthalmic Product Development, p.121-151

Ort / Verlag

Cham: Springer International Publishing

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Topical drugs to the eye, common among ophthalmic drugs, access the anterior chamber via corneal or noncorneal pathways with penetration across the cornea, an oil:water:oil matrix, preferred by low-molecular-weight lipophilic drugs. The kinetics of their transcorneal penetration also depends on the barrier integrity of the corneal epithelium. Over the years, we have measured time-dependent ocular surface dynamics and transcorneal kinetics of several fluorescent molecules (employed as drug surrogates) and nanoparticles using custom-built fluorometers: spot fluorometer and confocal scanning microfluorometer (CSMF), respectively. The spot fluorometer has enabled novel approaches to assess the efficacy of different vehicles for enhanced bioavailability of topical drugs. It has also quantified the variability in the ocular surface dynamics of topical drops. On the other hand, the CSMF has led to a microscopic view of the transport of fluorescent dyes across the cornea, highlighting the cellular barriers and partitioning of dyes. The data accrued from these observations have enabled rational modeling of the spatiotemporal corneal pharmacokinetics of topical drugs. Unlike the compartmental models, our models incorporate the physicochemical properties of the drugs to explain the kinetics of their penetration. In this chapter, we review our unique experimental observations and describe the framework of our pharmacokinetic model for topical drugs.