Details

Autor(en) / Beteiligte

• Frisch, Steven M

Titel

The Roles of Anoikis in Cervical Cancer

Ist Teil von

• Anoikis, 2021, p.127-136

Ort / Verlag

Switzerland: Springer International Publishing AG

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Cervical cancer is one of the most common malignancies in women worldwide. Tumor invasion and distant metastasis are among the main reasons for mortality in patients with cervical cancer. Resistance to anoikis is an important component of the multi-step cancer metastasis process. During this process, cancer cells utilize mechanisms to trigger survival signals and suppress death pathways, and take advantage of miRNAs or specific HPV oncogene variants to regulate anoikis. Chronic stress has been shown to contribute to tumor progression through norepinephrine-induced YAP1 activation and anoikis resistance. Norepinephrine binds to β-adrenergic receptors on the cancer cells to initiate downstream YAP signaling through cAMP/protein kinase A activation. YAP is dephosphorylated and translocated to the nucleus, protecting cancer cells from anoikis. YAP inhibitors may be useful for promoting anoikis and treating cervical and other cancers.