Details

Autor(en) / Beteiligte

• Kaufmann, Wolfgang
• Jacobsen, Matt C.
• Reichl, Franz-Xaver
• Schwenk, Michael

Titel

Examination of Organ Toxicity

Ist Teil von

• Regulatory Toxicology, p.117-127

Ort / Verlag

Cham: Springer International Publishing

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• As a result of their anatomy and physiology, the organs and tissues of animals and man may show different morphological responses and sensitivity to xenobiotics. Toxic responses can manifest systemically (e.g., the immune system) or may produce specific toxic effects in a single organ system (skin) or single organ (liver). Organ toxicity may therefore result from a direct and primary effect on a target organ or as a result of secondary effects in organs and tissues that have a physiological dependence on the primary target (Haschek 2009). The assessment of organ toxicity must therefore take into account the complex physiological interdependence of tissues and organs within the body.