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Harmonization of Infant Cortical Thickness Using Surface-to-Surface Cycle-Consistent Adversarial Networks
Ist Teil von
Medical Image Computing and Computer Assisted Intervention – MICCAI 2019, 2019-10, p.475-483
Ort / Verlag
Cham: Springer International Publishing
Erscheinungsjahr
2019
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Increasing multi-site infant neuroimaging datasets are facilitating the research on understanding early brain development with larger sample size and bigger statistical power. However, a joint analysis of cortical properties (e.g., cortical thickness) is unavoidably facing the problem of non-biological variance introduced by differences in MRI scanners. To address this issue, in this paper, we propose cycle-consistent adversarial networks based on spherical cortical surface to harmonize cortical thickness maps between different scanners. We combine the spherical U-Net and CycleGAN to construct a surface-to-surface CycleGAN (S2SGAN). Specifically, we model the harmonization from scanner X to scanner Y as a surface-to-surface translation task. The first goal of harmonization is to learn a mapping \documentclass[12pt]{minimal}
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\begin{document}$$G_X: X\rightarrow Y$$\end{document} such that the distribution of surface thickness maps from \documentclass[12pt]{minimal}
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\begin{document}$$G_X(X)$$\end{document} is indistinguishable from Y. Since this mapping is highly under-constrained, with the second goal of harmonization to preserve individual differences, we utilize the inverse mapping \documentclass[12pt]{minimal}
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\begin{document}$$G_Y: Y\rightarrow X$$\end{document} and the cycle consistency loss to enforce \documentclass[12pt]{minimal}
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\begin{document}$$G_Y(G_X(X))\approx X$$\end{document} (and vice versa). Furthermore, we incorporate the correlation coefficient loss to guarantee the structure consistency between the original and the generated surface thickness maps. Quantitative evaluation on both synthesized and real infant cortical data demonstrates the superior ability of our method in removing unwanted scanner effects and preserving individual differences simultaneously, compared to the state-of-the-art methods.