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DNA Sequence Alignment Method Based on Trilateration
Ist Teil von
Bioinformatics and Biomedical Engineering, p.271-283
Ort / Verlag
Cham: Springer International Publishing
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
The effective comparison of biological data sequences is an important and a challenging task in bioinformatics. The sequence alignment process itself is a way of arranging DNA sequences in order to identify similar areas that may have a consequence of functional, structural or evolutionary relations between them. A new effective and unified method for sequence alignment on the basic of trilateration, called CAT method, and using C (cytosine), A (adenine) and T (thymine) benchmarks is presented in this paper. This method suggests solutions to three major problems in sequence alignment: creating a constant favorite sequence, reducing the number of comparisons with the favorite sequence, and unifying/standardizing the favorite sequence by defining benchmark sequences.