Details

Autor(en) / Beteiligte

• Kamal-Eldin, Afaf

Titel

Antioxidative Activity of Vitamin E

Ist Teil von

• Vitamin E in Human Health, p.19-30

Ort / Verlag

Cham: Springer International Publishing

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Vitamin E includes lipophilic derivatives of chromanol having one, two, or three methyl substituents on the phenolic ring. Vitamin E molecules, mainly α- and γ-tocopherols, are the most important antioxidants in nature. Their antioxidant effect is optimum at a certain range of concentrations, above which the vitamin exhibits a loss of efficacy or a prooxidant effect depending on the external conditions, including the nature of existing lipids and interfacial compounds, temperature, etc. Recent understandings of antioxidant mechanisms highlighted the importance of the microenvironment and how it influences synergistic and antagonistic interactions. Vitamin E components are not only antioxidants protecting polyunsaturated fatty acids from free radical attack, but they also seem to have stabilizing role in cell membranes, where molecular organization plays a very important role. In biological systems, α-tocopherol functions as part of an integrated antioxidant defense system in concert with vitamin C and other hydrophilic components. This chapter reviews the chemical basis of the antioxidant mechanism of vitamin E according to contemporary knowledge.