Details

Autor(en) / Beteiligte

• Anderson Berry, Ann L.
• Hanson, Corrine K.

Titel

The Role of Vitamin E in Pregnancy

Ist Teil von

• Vitamin E in Human Health, p.405-417

Ort / Verlag

Cham: Springer International Publishing

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Oxidative stress has been associated with low birth weight, preterm delivery, and preeclampsia, all important negative maternal or neonatal outcomes of pregnancy. Vitamin E, specifically RRR-α-tocopherol, has potent antioxidant effects that may help mitigate these risks if intake is optimal during pregnancy. Many complications of pregnancy and the neonatal period are augmented by inflammation making the task of defining optimal vitamin E status and antioxidant capacity during pregnancy a worthwhile endeavor. Clinical supplementation trials of vitamin E during pregnancy as reviewed by a 2015 Cochrane review are inconclusive or draw contradictory conclusions and have designs that do not lead to robust data for analysis. Additional information regarding placental regulation of α- and γ-tocopherols, fetal tissue incorporation, and fetal serum concentrations of tocopherol metabolites are other areas for continued research. A more complete understanding of vitamin E status of the pregnant woman and its impact on the developing fetus as well as associations with pregnancy outcomes such as length of gestation, mode of delivery, and associations with preeclampsia, pregnancy-induced hypertension, and gestational diabetes is critical to improving pregnancy outcomes. Considerable scientific work remains necessary to fully understand the role of vitamin E in fertility and pregnancy and its ability to optimize maternal and neonatal outcomes.