Details

Autor(en) / Beteiligte

• Eckert, Gunter P.

Titel

The Role of Vitamin E in Aging and Alzheimer’s Disease

Ist Teil von

• Vitamin E in Human Health, p.325-344

Ort / Verlag

Cham: Springer International Publishing

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Rising life expectancy is leading to an increasing number of patients with age-related diseases, including neurodegenerative disorders such as Alzheimer’s disease (AD). One of the hallmarks of AD are elevated markers of oxidative damage, as increased concentrations of oxidized nucleic acids, proteins, and lipids have been found in AD brains. Vitamin E is an essential antioxidant micronutrient and plays an important role in protecting cells from oxidative damage, such as the harmful effects of free radicals observed in brain aging and AD. Animal studies showed sufficient evidence to consider a treatment with vitamin E for patients suffering from AD. However, the results of clinical studies on AD patients are conflicting. To date, there is no convincing evidence from meta-analyses on randomized, placebo-controlled trials that vitamin E alone or in combination with other antioxidants prevents the progression or improves cognitive function in people with mild cognitive impairment (MCI) or AD. Additional research is needed to explore the effects of vitamin E treatment on other clinically relevant outcomes, such as quality of life. Furthermore, and in addition to the practical challenges when conducting randomized trials among older people with AD, key issues that need to be carefully considered for further vitamin E therapy trials include dosing, timing, mono- or multimodal therapy, and selection of different vitamers including γ-tocopherol and tocotrienols.