Details

Autor(en) / Beteiligte

• Pablo, Paola de
• Lo, Grace
• McAlindon, Timothy E.

Titel

Nutrition and Nutritional Supplements and Osteoarthritis

Ist Teil von

• Nutrition and Rheumatic Disease, p.125-158

Ort / Verlag

Totowa, NJ: Humana Press

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• • There are numerous mechanisms by which micronutrients might be expected to influence the development or progression of osteoarthritis, but there has been insufficient research to draw definitive conclusions • One observational study suggested a protective effect of vitamin C for progression of osteoarthritis of the knee. Intake of vitamin E and β-carotene bore no relationship to osteoarthritis incidence or progression in that study, suggesting that the mechanism of benefit of vitamin C may be mediated through nonantioxidant properties • Clinical trials of vitamins E, C, and A and selenium have produced negative or inconsistent results • Epidemiological data for vitamin D in the treatment of symptoms and structural progression of osteoarthritis are conflicting. A randomized controlled trial is currently underway to address the efficacy of vitamin D in both the treatment of symptoms and structural progression in osteoarthritis. • Epidemiological data for vitamin K as a disease modifying micronutrient in osteoarthritis are conflicting. Randomized controlled trials are currently underway to address the efficacy of vitamin K in both the treatment of symptoms and structural progression in osteoarthritis. • There have been numerous positive clinical trials of glucosamine and chondroitin products for OA that have shown them to be well tolerated; however, interpretation of these trials is clouded by issues of biological plausibility, heterogeneity, publication bias, inconsistent results and methodological problems.