Details

Autor(en) / Beteiligte

• Shen, Aiguo
• Liao, Zhangxiu
• Wang, Hui
• Goan, Iiho
• Wu, Yong
• Wang, Xiaohua
• Yu, Zhenyu
• Hu, Jiming

Titel

Study on the

Ist Teil von

• Journal of Biomedical Optics, 2007-06, Vol.12 (3), p.034003-034009

Erscheinungsjahr

2007

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The feasibility of a novel and efficient diagnostic method for liver fibrosis using Raman spectroscopy is studied. Confocal Raman spectroscopy (CRS) is utilized to monitor the molecular changes of hepatic stellate cells (HSCs) as well as activation. activation was induced by growth in uncoated plastic plates, while the activation is induced by a single intraperitoneal injection of carbon tetrachloride . The biochemical changes of HSCs during activation such as the loss of retinoid, the increase of -helical protein, and the increased production of extracellular matrix proteins are observed by CRS. A user-friendly autoclassifying system is also developed to classify Raman spectra of liver injury tissues with a 90 accuracy rate. Raman spectroscopy combined with a fiber optical probe could be potentially accomplished for detection, which can lead to a novel and efficient diagnosis for liver fibrosis.