Details

Autor(en) / Beteiligte

• Cima, Igor
• Wen Yee, Chay
• Iliescu, Florina S.
• Min Phyo, Wai
• Hon Lim, Kiat
• Iliescu, Ciprian
• Han Tan, Min

Titel

Label-free isolation of circulating tumor cells in microfluidic devices: Current research and perspectives

Ist Teil von

• Biomicrofluidics, 2013-01, Vol.7 (1), p.11810-11810

Ort / Verlag

United States: American Institute of Physics

Erscheinungsjahr

2013

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• This review will cover the recent advances in label-free approaches to isolate and manipulate circulating tumor cells (CTCs). In essence, label-free approaches do not rely on antibodies or biological markers for labeling the cells of interest, but enrich them using the differential physical properties intrinsic to cancer and blood cells. We will discuss technologies that isolate cells based on their biomechanical and electrical properties. Label-free approaches to analyze CTCs have been recently invoked as a valid alternative to “marker-based” techniques, because classical epithelial and tumor markers are lost on some CTC populations and there is no comprehensive phenotypic definition for CTCs. We will highlight the advantages and drawbacks of these technologies and the status on their implementation in the clinics.