Details

Autor(en) / Beteiligte

• Araújo Filho, Gerardo Maria de
• Gomes, Francinaldo Lobato
• Mazetto, Lenon
• Marinho, Murilo Martinez
• Tavares, Igor Melo
• Caboclo, Luís Otávio Sales Ferreira
• Yacubian, Elza Márcia Targas
• Centeno, Ricardo Silva

Titel

Pre-surgical mood disorders associated to worse post-surgical seizure outcome in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis

Ist Teil von

• Journal of epilepsy and clinical neurophysiology, 2012-03, Vol.18 (1), p.21-25

Ort / Verlag

Liga Brasileira de Epilepsia (LBE)

Erscheinungsjahr

2012

Beschreibungen/Notizen

• OBJECTIVES: This study aims at verifying the impact of pre-surgical PD on seizure outcome in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis (TLE-MTS). METHODS: After previous consent, retrospective data from 115 surgically treated (corticoamygdalohyppocampectomy) TLE-MTS patients (65 females; 56.5%) were analyzed. Psychiatric evaluations were performed through DSM-IV criteria. Engel IA was established as a favorable prognosis. RESULTS: Forty-five patients (41.6%) were classified as Engel IA, while 47 (40.8%) presented pre-surgical PD. Depression (OR=5.11; p=0.004) appeared as a risk factor associated to a non-favorable seizure outcome. CONCLUSION: In patients with refractory TLE-MTS, the presence of depression predicts an unfavorable outcome.