Details

Autor(en) / Beteiligte

• Peixoto-Santos, José Eduardo
• Galvis-Alonso, Orfa Yineth
• Velasco, Tonicarlo R.
• Kandratavicius, Ludmyla
• Assirati Jr, João Alberto
• Carlotti, Carlos Gilberto
• Scandiuzzi, Renata Caldo
• Serafini, Luciano Neder
• Leite, João Pereira

Titel

Different levels of MT-I/II between patients with MTLE with or without seizure generalization: does hippocampal MT-I/II affects seizure spread, or does seizure spread promotes differential expression of MT-I/II?

Ist Teil von

• Journal of epilepsy and clinical neurophysiology, 2012-03, Vol.18 (1), p.16-20

Ort / Verlag

Liga Brasileira de Epilepsia (LBE)

Erscheinungsjahr

2012

Link zum Volltext

Beschreibungen/Notizen

• In the central nervous system, zinc is released along with glutamate during neurotransmission and, in excess, can promote neuronal death. Experimental studies have shown that metallothioneins I/II (MT-I/II), which chelate free zinc, can affect seizures and reduce neuronal death after status epilepticus. Our aim was to evaluate the expression of MT-I/II in the hippocampus of patients with temporal lobe epilepsy (TLE). Hippocampi from patients with pharmacoresistant mesial temporal lobe epilepsy (MTLE) were evaluated for expression of MT-I/II and for neuronal, astroglial, and microglial populations. Compared to control cases, MTLE group displayed widespread increase in MT-I/II expression, astrogliosis and reduced neuronal population. MT-I/II levels did not correlate with any clinical variables, but patients with secondary generalized seizures (SGS) had less MT-I/II than patients without SGS. In conclusion, MT-I/II expression was increased in hippocampi from MTLE patients and our data suggest that it may be associated with different seizure spread patterns.